Background: Covid-19 is a viral illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first reported during December, 2019, in Wuhan, Hubei in China. On Thursday, the first of October 2020, the White House of the USA declared that the president of the USA, Donald Trump had a positive test for SARS-CoV-2. He initially had mild symptoms which included mostly, hoarseness, lethargy, and fatigue. The treatment received by a patient “Donald Trump” who was considered the most powerful person in the world is studied, and this paper assumed that all the patients in the world are as important as Mr. Trump and tries to offer the best evidence-treatment for them. Patients and methods: Most media including the CNN television channel rightly confirmed that Mr. Trump has been treated by the best doctors in the world with best therapies that could possibly help him in defeating the virus. The CNN, in various programs during the first week of October, emphasized that, American citizens with Covid-19 are not receiving the same treatments as their president Donald Trump. Results: Trump aged 74 years and initially had mild symptoms which included mostly, hoarseness, lethargy, and fatigue. His age, obesity and mildly elevated cholesterol were considered risk factors that may reduce the likelihood of having very favorable outcome. It was reported that he initially took hydroxychloroquine, an anti-malarial drug. The use of a therapeutic approach including experimental antibody therapy, remdesivir and dexamethasone has not been reported as a treatment for one patient before other than Mr. Trump. Obviously, of the three important therapies, only dexamethasone can be offered to almost all the patients with covid-19. Conclusion: It seems that, the most important factors that made treatment of Donald Trump effective and successful are: 1-The early institution of therapy regardless of the generally accepted recommendations. 2-The use of multiple drugs as none of the available drug alone can guarantee successful treatment.

Background and Purpose: We aimed to evaluate the demographic features, clinical manifestations, course of disease, and outcome of children with Influenza and Influenza complications. Methods: In the winter season -just before the COVID 19 outbreak- between October 2019 and March 2020, the cases with Influenza diagnosed by rt-PCR (real time polymerase chain reaction) requiring hospitalization retrospectively were evaluated with hospital records. Results: A total 36 children were hospitalized with Influenza virus infection. The most frequent presentations of the subjects were malaise and fever. Other clinical presentations consisted of vomitting (36.1%), abdominal pain (30.5%), myalgia (27.7%), diarrhea (25%), dry cough (19.4%), and arthralgia (11.1%). There were respiratory distress in 19 patients (52.7%) in our cohort. The most frequent underlying disease requiring hospitalization was neurological diseases. Conclusions and Recommendation: The Influenza infection was associated with a wide variety of clinical findings during the hospital admission in pediatric patients. Immunization programs for Influenza should be considered for all children aged > 6 months, and should be also targeted the pediatric population that likely to be hospitalized with predisposing medical conditions- particularly neurological- every influenza season. Encouraging the use of Influenza vaccines will provide a decrease in Influenza that have similar presentations of COVID-19.

CYP3A4*1B is a single nucleotide polymorphism of CYP3A4 and is associated with prostate cancer which exhibits higher nifedipine oxidase activity in liver. This research provides details of the effects of structural variation and medium effects for the recently reported split-oligonucleotide (tandem) probe system for excimers-based fluorescence detection of DNA. In this approach the detection system is split at a molecular level into signal-silent components, which must be assembled correctly into a specific 3-dimensional structure to ensure close proximity of the excimer partners and the consequent excimer fluorescence emission on excitation. The model system consists of two 11-mer oligonucleotides, complementary to adjacent sites of a 22-mer DNA target. Each oligonucleotide probeis equipped with functions able to form an excimer on correct, contiguous hybridization. The extremely rigorous structural demands for excimer formation and emission required careful structural design of partners for excimer formation, which are here described. This study demonstrates that the excimer formed emitted at ~480 nm with alarge Stokes shift (~130 - 140 nm).

The present article sociologically appraises how the two variables of economic growth and population growth are related. The two variables had a different relationship with each other before industrialization started as compared with the modern era. In older times, when societies were agricultural, there seemed to be no contradiction between the two. At that time, as many as children were born, used to get engaged in agricultural sector. Moreover, at that time, death rate was also high. But, later and due to the emergence of industrialization, technologies and mechanization, gradually contradiction of economic growth versus population growth appeared. This is where socio-clinical study of economic growth and population growth finds its necessity. Sociologically speaking, Asian countries need to pay more attention to the two variables, and thereby minimize the emerging contradiction. While average life expectancy is currently over 73 years in Asia (WPDS, 2020), Asian countries must predict feeding, nursing, housing and medications of such aging people for the years to come. It must be notified that population aging as a new trend is the outcome of economic growth. Immune systems of all increasing aging people must be on the agenda in a socio-clinical framework.

Background: Cherubism is a very rare, mostly a childhood condition that can be horribly disfiguring. We have previously reported our extensive experiences with the diagnosis of rare genetic disorders in a plethora of publications. We have previously reported a large number of rare conditions in Iraq, and we have also helped physicians in the diagnosis and publication of rare syndromes observed in other countries. The aim of this papers is to help physicians in advancing the diagnostic skills in the field of clinical genetics by reviewing briefly a rare syndrome that have not been reported in Iraq, but it is associated with certain clinical characteristics that allow an early diagnosis when seen for the first time. Patients and methods: During the last week of January, 2021, several TV channels presented and discussed the problem of two brothers from Egypt who were considered to have a very rare poorly defined condition that has been associated with progressive disfigurement which resulted in embarrassing social encounters. The cases of the two brothers are presented. Results: The older brother aged 15 and the younger brother aged 14 years. Both had abnormal bilateral and symmetric growth of the jaw resulting in a wide jaw appearance and a round and swollen appearance of cheeks. They also had no teeth on the lower jaw and loose or misplaced teeth on the upper jaw. The parents and a third brother were unaffected. Both children didn’t have mental retardation. The older brother had more severe disfigurement, and many people were asking him to remove the mask he is wearing. He also had very poor vision of left eye resulting from the pressure effect and upward displacement of the eye. The younger brother had a surgical operation to remove a benign tumor from the lower jaw which reduced his disfigurement. Conclusion: Awareness of doctors with this condition “Cherubism” is helpful, and denosumab can be tried in severe cases based on the evidence provided by Bar Droma et al (2020).